Recombinant Human IL-10 Protein

Recombinant human IL-10 is produced by the mammalian system, with the target gene encoding Ser19-Asn178 expressed.

Product Specifications

Background

Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene.IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins.Consequently, the functional receptor consists of four IL-10 receptor molecules. IL-10 binding induces STAT3 signalling via the phosphorylation of the cytoplasmic tails of IL-10 receptor 1 + IL-10 receptor 2 by JAK1 and TYK2 respectively.

Synonyms

IL10, CSIF, GVHDS, IL-10, IL10A, TGIF, interleukin 10

Source

Human Cells

Applications

SDS-PAGE

Endotoxin

<0.01 EU/µg by LAL test

Purity

>95%by SDS-PAGE

Buffer

Lyophilized from a 0.2 μm filtered solution of PBS,4%Mannitol, pH 7.4.

Reconstitution

Dissolve the lyophilized protein in distilled water (It is not recommended to reconstitute to a concentration<100μg/ml.)

References & Citations

Eskdale J, Kube D, Tesch H, Gallagher G (1997) . "Mapping of the human IL10 gene and further characterization of the 5' flanking sequence". Immunogenetics. 46 (2) : 120–128. Mosser DM, Zhang X (December 2008) . "Interleukin-10: new perspectives on an old cytokine". Immunological Reviews. 226 (1) : 205–218.