Recombinant Human XIAP protein (His tag)
Product Specifications
Background
XIAP (X-chromosome linked inhibitor of apoptosis) is a member of the apoptosis (IAP) family of proteins that inhibit caspases. The BIR2 domain of XIAP inhibits caspase-3 and caspase-7. The ability of XIAP to inhibit caspases is prevented by SMAC/Diablo through binding to XIAP-BIR2 and-BIR3 domains.
Abbreviation
XIAP
Synonyms
Baculoviral IAP repeat-containing protein 4; E3 ubiquitin-protein ligase XIAP; IAP-like protein; Inhibitor of apoptosis protein 3; RING-type E3 ubiquitin transferase XIAP; X-linked inhibitor of apoptosis protein; XIAP
UniProt
P98170
Accession Number
P98170
Expression System
E.coli
Tag
N-His & C-His
Sequence
Met 1-Ser 497
Field of Research
Cancer; Cell Biology; Metabolism
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
54.6 kDa
Observed Molecular Weight
54 kDa
Species
Human
Available Sizes
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