Freeβ-HCG Protein (Active)

Recombinant full length human freeβ-HCG protein with molecular weight 19 kDa.

Product Specifications

Background

Human chorionic gonadotropin (CG) is a glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10 to 12 days after conception. It is a glycoprotein composed of 237 amino acids with a molecular mass of 25.7 kDa. It is heterodimeric, with an α (alpha) subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and β (beta) subunit that is unique to hCG. β subunit is secreted by some cancers including seminoma, choriocarcinoma, germ cell tumors, hydatidiform mole formation, teratoma with elements of choriocarcinoma, and islet cell tumor. Combined with alpha-fetoprotein, β-HCG is an excellent tumor marker for the monitoring of germ cell tumors.

Synonyms

Free chorionic gonadotropin beta subunit, free hCG-b, freeβ-HCG

Source

E. Coli

Applications

ELISA; SDS-PAGE

Purity

>95% by SDS-PAGE

Buffer

Each vial contains 10 mM PBS (pH 7.4) with 0.05% NaN3.

References & Citations

Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW (June 1994) . "Crystal structure of human chorionic gonadotropin". Nature 369 (6480) : 455–61.