UNC8899
UNC8899 is a VHL-recruiting STING PROTAC degrader (DC50: 0.0.924 μM) . UNC8899 can be used for viral or bacterial infection research (Blue: VHL ligand, Black: linker; Pink: STING inhibitor) [1].
Product Specifications
UNSPSC
12352005
Target
PROTACs; STING
Type
Reference compound
Related Pathways
Immunology/Inflammation; PROTAC
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/unc8899.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCOCCOCCC(N[C@@H](C(N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@H](C1)O)=O)C(C)(C)C)=O)C4=CC5=C(C(OC)=C4)N(C/C=C/CN6C(NC(C7=CC(C)=NN7CC)=O)=NC8=C6C(OCCCN9CCOCC9)=CC(C(N)=O)=C8)C(NC(C%10=CC(C)=NN%10CC)=O)=N5
Molecular Formula
C71H91N17O13S
Molecular Weight
1422.65
References & Citations
[1]Zhu Z, et al. Development of VHL-recruiting STING PROTACs that suppress innate immunity. Cell Mol Life Sci. 2023 May 14;80 (6) :149.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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