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Recombinant human IL-16 protein

Interleukin-16 (IL16) is an immunomodulatory cytokine, which induces lymphocyte migration, expression of proinflammatory IL-1beta, IL6 and tumour necrosis factor-alpha (TNFalpha), and modulates apoptosis. This protein is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. Also, several central nervous system diseases and may play a role in promoting inflammatory responses. Recombinant human IL16, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Interleukin 16, Lymphocyte chemoattractant factor, LCF, prointerleukin 16, prIL-16

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

15.5 kDa (150aa) confirmed by MALDI-TOF

Additionnal Information

IL16, ILP0801-10 µg, ILP0801-20 µg, ILP0801-50 µg, ILP0801-100 µg, ILP0801-250 µg, ILP0801-500 µg, ILP0801-1 mg, ILP0801-10, ILP0801-20, ILP0801-50, ILP0801-100, ILP0801-250, ILP0801-500, ILP0801-1

References & Citations

Bernstein HB., et al. (2006) J Immunol. 177 (6) :3669-76.; ; McFadden C J., et al. (2007) J Immunol. 179 (10) :6439-45.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_004504.3

Uniprot Accession Number

Q14005

Species

Human

AA Sequence

MPDLNSSTDS AASASAASDV SVESTAEATV CTVTLEKMSA GLGFSLEGGK GSLHGDKPLT INRIFKGAAS EQSETVQPGD EILQLGGTAM QGLTRFEAWN IIKALPDGPV TIVIRRKSLQ SKETTAAGDS

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