Recombinant human GADD45 gamma protein
GADD45G is a member of GADD45 family (GADD45alpha, beta, and gamma) that are nuclear proteins to interact with various proteins implicated in stress responses and cell-cycle-related proteins. The function of GADD45 proteins is involved in growth-regulatory mechanisms and apoptosis. GADD45G protein responds to environmental stresses by mediating activation of p38/JNK pathway via MTK1/MEKK4 kinase and its transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. Recombinant GADD45G protein was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
17.8 kDa (160aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Takekawa M., et al. (1998) Cell 95 (4), 521-30; ; Zerbini LF., et al. (2004) PNAS 101 (37), 13618-23;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 7.5)
Scientific Category
Cell Cycle
NCBI Accession Number
NP_006696.1
Uniprot Accession Number
O95257
Species
Human
AA Sequence
Frequently Asked Questions
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