LMNB2 Rabbit Polyclonal Antibody
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. Defects in LMNB2 are a cause of partial acquired lipodystrophy (APLD), which is a rare childhood disease characterized by loss of subcutaneous fat from the face and trunk.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
LMNB2
Swiss Prot
Q03252 Human, P21619 Mouse,
Cellular Locus
Nucleus inner membrane
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide corresponding to of Human LMNB2 aa 571-620 / 620.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
HeLa cell lysate, HepG2 cell lysate, NIH/3T3 cell lysate, C6 cell lysate, HeLa, mouse embryonic stem cells, human colon cancer tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:2,000 ;IF-Cell: 1:250 ;IHC-P: 1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 70 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No
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