Recombinant mouse Cathepsin C/DPPI protein

Cathepsin C/DPPI, also known as dipeptidyl peptidase I , is a lysosomal exo-cysteine protease belonging to the peptidase C1 protein family, a subgroup of the cysteine cathepsins. It catalyses excision of dipeptides from the N-terminus of protein and peptide substrates, except if the amino group of the N-terminus is blocked. Also, It appears to be a central coordinator for activation of many serine proteases in immune/inflammatory cells. Defects in the Cathepsin C have been shown to be a cause of Papillon-Lefevre disease, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Also, It plays a key role in the activation of several degradative enzymes linked to tissue destruction in inflammatory diseases. Recombinant mouse Cathepsin C, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Product Specifications

Specifications

Specific activity is > 50,000 pmol/min/ug and is defined as the amount of enzyme that hydrolyze 1pmole of Gly-Arg-AMC per minute at pH 6.0 at 37C.

Product Name Alternative

Cathepsin C, AI047818, CatC, DP, DPP1, DPPI, Cathepsin J, Dipeptidyl peptidase isoform 1, Dipeptidyl peptidase 1, Dipeptidyl transferase, CTSC

Expression System

HEK293

Antigen Species

Mouse

Tag

His-Tag

Applications

SDS-PAGE, Enzyme Activity

Concentration

0.5 mg/mL (determined by Absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Bioactivity

Specific activity is > 50,000 pmol/min/ug and is defined as the amount of enzyme that hydrolyze 1pmole of Gly-Arg-AMC per minute at pH 6.0 at 37C.

Molecular Weight

50.5kDa (444aa)

Additionnal Information

ATGP4093-10 µg, ATGP4093-20 µg, ATGP4093-50 µg, ATGP4093-100 µg, ATGP4093-250 µg, ATGP4093-500 µg, ATGP4093-1 mg, ATGP4093-10, ATGP4093-20, ATGP4093-50, ATGP4093-100, ATGP4093-250, ATGP4093-500, ATGP4093-1