ZW10 antibody
Product Specifications
Background
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131) . Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER) ; the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241) .
Synonyms
Centromere/kinetochore protein zw10 homolog|ZW10
Gene ID
9183
UniProt
O43264
Host
Rabbit
Reactivity
Human
Immunogen
ZW10, kinetochore associated, homolog (Drosophila)
Target
ZW10
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Cell Division and Proliferation, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
90 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
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