Recombinant human Alpha 1-Acid Glycoprotein 1/ORM1 protein
Alpha 1-Acid Glycoprotein 1 also known as ORM1, is a member of the inositol calycin superfamily. It is an acute phase plasma protein synthesized by the liver. The specific function of this protein has not yet been determined. However, it may be involved in aspects of immunosuppression. The protein is believed to regulate the interaction between blood cells and endothelial cells, and together with haptoglobin and C reactive protein, also regulates the extravasation of the cells during infection and inflammation. Expression of ORM1 is induced by acute-phase stimulatory agents such as bacterial lipopolysaccharides. Recombinant human Alpha 1-Acid Glycoprotein 1/ORM1, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Orosomucoid-1, ORM, AGP1, AGP-A, HEL-S-153w
Expression System
HEK293
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
22.4kDa (189aa)
Additionnal Information
References & Citations
Umetsu K., et al. (1986) Hum Genet. 71:223-224.; ; Carter K C., et al. (1991) Biochim. Biophys. Acta. 1089:197-205.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_000598.2
Uniprot Accession Number
P02763
Species
Human
N Terminal Sequence
Gln 19
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