Recombinant human CD66b/CEACAM8 protein

CEACAM-8, also known as CD66b, is a cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. It mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Its main function is cell adhesion, cell migration, and pathogen binding. However, its biological functions are largely unknown in eosinophils. It has been reported that CEACAM-8 is highly expressed on the surface of human peripheral blood eosinophils isolated from healthy individuals and used as granulocyte marker. Recombinant human CEACAM-8, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS - PAGE

Molecular Weight

32.3kDa (292aa)

Additionnal Information

Carcinoembryonic antigen-related cell adhesion molecule 8, CD67 antigen, Carcinoembryonic antigen CGM6, Non-specific cross-reacting antigen NCA-95, CD66b, CGM6, CD67, NCA-95, ATGP4004-10 µg, ATGP4004-50 µg, ATGP4004-100 µg, ATGP4004-200ug, ATGP4004-250 µg, ATGP4004-500 µg, ATGP4004-1 mg, ATGP4004-10 µg, ATGP4004-20 µg, ATGP4004-50 µg, ATGP4004-100 µg, ATGP4004-250 µg, ATGP4004-500 µg, ATGP4004-1 mg, ATGP4004-10, ATGP4004-20, ATGP4004-50, ATGP4004-100, ATGP4004-250, ATGP4004-500, ATGP4004-1

References & Citations

Kuroki M., et al, (2001) J Leukoc Biol. 70:543-550.; ; Ilie M., et al, (2012) Cancer. 118:1726-1737.; ; Posabella A, et al, (2020) J Cancer Res Clin Oncol. 146:127-136.;