Recombinant human CD299/CLEC4M protein
CD299, as known as DC-SIGNR and CLEC4M, is a type II integral membrane protein that is 77% amino acid identical to CD209/DC-SIGN, an HIV gp120-binding protein. This protein is probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. It may mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. CD299 is a receptor for ICAM3, binding to mannose-like carbohydrates. It also recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including tuberculosis mycobacteria, and viruses including Ebola, hepatitis C, HIV-1, influenza A, West Nile virus and the SARS-CoV acute respiratory syndrome coronavirus. Recombinant human CD299, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS - PAGE
Molecular Weight
64.8kDa (570aa)
Additionnal Information
References & Citations
Gijzen K., et al, (2008) Exp Hematol. 36:860-870.; ; Johnson TR, et al, (2012) J Virol. 86:1339-1347.; ; Xia HB, et al, (2020) Oncol Lett. 19:69-76.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_055072
Uniprot Accession Number
Q9H2X3
Species
Human
N Terminal Sequence
Ala
AA Sequence
Frequently Asked Questions
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