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Recombinant human BMP-2 protein

BMP-2, also known as Bone morphogenetic protein 2, is multi-functional growth factor that belongs to the transforming growth factor beta (TGF beta) superfamily. It plays an important role in embryonic dorsal-ventral patterning, organogenesis, limb bud formation, and bone formation and regeneration. BMP-2 also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells, and is required for cardiac contractility. Recombinant human BMP2 was expressed in E. coli and purified by conventional chromatography techniques.

Product Specifications

Specifications

Human BMP-2 stimulates alkaline phosphatase in the ATDC5 mouse chondrogenic cells. The ED50 range ≤ 100 ng/mL.

Product Name Alternative

Bone morphogenetic protein 2, BMP-2A

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE, Bioactivity

Concentration

1 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Bioactivity

Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is ≤ 100 ng/mL.

Molecular Weight

13 kDa (115aa)

Additionnal Information

BMP2, Bone morphogenetic protein 2, BMP-2A, ATGP3940-10 µg, ATGP3940-20 µg, ATGP3940-50 µg, ATGP3940-100 µg, ATGP3940-250 µg, ATGP3940-500 µg, ATGP3940-1 mg, ATGP3940-10, ATGP3940-20, ATGP3940-50, ATGP3940-100, ATGP3940-250, ATGP3940-500, ATGP3940-1

References & Citations

Chen D., et al. (2004) . Growth factors. 22 (4) :233-41; ; Schliephake H., et al. (2005) . Clin Oral Implants Res. 17 (6) :666-72

Other References

Tanaka M, et al. Physico-Chemical, In Vitro, and In Vivo Evaluation of a 3D Unidirectional Porous Hydroxyapatite Scaffold for Bone Regeneration. (Materials (Basel) . 2017) {https://pubmed.ncbi.nlm.nih.gov/28772390/}; ; Tanaka M, et al. In Vitro and In Vivo Evaluation of a Three-Dimensional Porous Multi-Walled Carbon Nanotube Scaffold for Bone Regeneration. (Nanomaterials (Basel) . 2017) {https://pubmed.ncbi.nlm.nih.gov/28336879/}; ; Qi S, et al. Cellular Internalization-Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein-Mediated Protection of Stem Cells. (Small. 2019) {https://pubmed.ncbi.nlm.nih.gov/30488562/}

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 10 mM Sodium acetate (pH 3.5)

Scientific Category

Signal Transduction

NCBI Accession Number

NP_001191

Uniprot Accession Number

P12643

Species

Human

AA Sequence

MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR

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