Recombinant human B7-2/CD86 protein

B7-2/CD86, also known as T-lymphocyte activation antigen CD86 isoform 1, is a variably glycosylated protein in the B7 family. These family members play important roles in immune activation and the maintenance of immune tolerance. It is expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival and exists predominantly as a monomer on cell surfaces. Also, it interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells that it induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. Recombinant Human B7-2/CD86, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

B7-2/CD86, CD86, B7-2, B7.2, B70, CD28LG2, LAB72, T-lymphocyte activation antigen CD86, Activation B7-2 antigen, B70, BU63, CTLA-4 counter-receptor B7.2, FUN-1

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

25.6 kDa (223aa)

Additionnal Information

B72, CD86, ATGP3895-10 µg, ATGP3895-20 µg, ATGP3895-50 µg, ATGP3895-100 µg, ATGP3895-250 µg, ATGP3895-500 µg, ATGP3895-1 mg, ATGP3895-10, ATGP3895-20, ATGP3895-50, ATGP3895-100, ATGP3895-250, ATGP3895-500, ATGP3895-1, ATGP3895-10 µg, ATGP3895-20 µg, ATGP3895-50 µg, ATGP3895-100 µg, ATGP3895-250 µg, ATGP3895-500 µg, ATGP3895-1 mg, ATGP3895-10, ATGP3895-20, ATGP3895-50, ATGP3895-100, ATGP3895-250, ATGP3895-500, ATGP3895-1