Anti-Hu CD127 Purified
CD127, a 60-90 kDa type I transmembrane glycoprotein, serves as the alpha subunit of the IL-7 receptor. It heterodimerizes with CD132, which is the common interleukin receptor gamma chain. CD127-mediated signaling promotes cell survival and is essential for lymphocyte development, including V (D) J recombination. Defects in CD127 can cause severe combined immunodeficiency (SCID) . It is expressed in common lymphoid progenitors, B and T cell precursors (except CD4/CD8 double positive thymocytes), and mature T cell subpopulations. Majority of CD127-CD4+ T cells are Treg cells.
Product Specifications
Certification
RUO
Target Antigen
CD127
Clone
RHIQB010
Applications
FC (QC tested)
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The recombinant mouse monoclonal antibody rHIQB010 recognizes an extracellular epitope of human CD127, the alpha subunit of IL-7 receptor.
Applications Notes
Flow cytometry: Recommended dilution: 0.5-4 μg/ml.
Species
Human
Isotype
Mouse IgG1
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