Recombinant human IL-3R alpha/IL3RA protein
IL3RA, also known as interleukin 3 receptor subunit alpha isoform 1, is a single-pass type 1 membrane protein which belongs to the type 1 cytokine receptor family and type 5 subfamily. This protein is a pleiotropic cytokine produced primarily by activated T cells or mast cells. Also, the specific alpha subunit of the interleukin 3 receptor is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. Recombinant human IL3RA, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Interleukin 3 receptor subunit alpha isoform 1, IL3RA, CD123, hIL-3Ra, IL3R
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
34.1 kDa (295aa)
Additionnal Information
References & Citations
Kosugi H., et al, (1995) Biochem. Biophys. Res. Commun. 208:360-367.; ; Yoshimura A., et al, (1995) EMBO J. 14:2816-2826.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_002174
Uniprot Accession Number
P26951
Species
Human
N Terminal Sequence
Ala
AA Sequence
Frequently Asked Questions
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