Recombinant mouse IGFBP-6 protein

Igfbp6, also known as insulin-like growth factor-binding protein 6, binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. It is a cysteine-rich protein with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. It plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence and IGF affinity. Recombinant mouse Igfbp6, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Insulin-like growth factor-binding protein 6, Igfbp6, IGFBP-6, IBP 6, IBP-6, IBP6, IBP6_HUMAN, IGF binding protein 6, IGF-binding protein 6, IGFBP 6, IGFBP-6, IGFBP6, Insulin like growth factor binding protein 6, Insulin-like growth factor-binding protein 6

Expression System

Baculovirus

Antigen Species

Mouse

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

23.7 kDa (221aa)

Additionnal Information

IGFBP6, Insulin-like growth factor-binding protein 6 , Igfbp6, IGFBP-6, IBP 6, IBP-6, IBP6, IBP6_HUMANIGF binding protein 6, IGF-binding protein 6IGFBP 6, IGFBP-6, IGFBP6, Insulin like growth factor binding protein 6, Insulin-like growth factor-binding protein 6, ATGP3411-10 µg, ATGP3411-20 µg, ATGP3411-50 µg, ATGP3411-100 µg, ATGP3411-250 µg, ATGP3411-500 µg, ATGP3411-1 mg, ATGP3411-10, ATGP3411-20, ATGP3411-50, ATGP3411-100, ATGP3411-250, ATGP3411-500, ATGP3411-1

References & Citations

Shalamanova L., et al. (2008) Mol Cell Endocrinol. 295:18-23.; ; Bach LA., et al. (1999) Horm Metab Res. 31:226-234.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 40% glycerol

Scientific Category

Signal Transduction

NCBI Accession Number

NP_032370

Uniprot Accession Number

P47880

Species

Mouse

N Terminal Sequence

Ala26

AA Sequence

ALAGCPGCGA GMQTGCRGGC VEEEDAGSPA DGCTEAGGCL RREGQPCGVY SPKCAPGLQC QPRENEEAPL RALLIGQGRC QRARGPSEET TKESKPQGGA SRSRDTNHRD RQKNPRTSAA PIRPNPVQDS EMGPCRRHLD SVLQQLQTEV FRGGARGLYV PNCDLRGFYR KQQCRSSQGN RRGPCWCVDP MGQPLPVSPD GQGSTQCSAR SSGLEHHHHH H