Recombinant human SIVA1 protein
Apoptosis regulatory protein Siva isoform 1, also known as SIVA1, is a death domain-containing proapoptotic protein identified as an intracellular ligand of CD27 and of the glucocorticoid-induced TNFR family-related gene, which are two members of the TNFR family expressed on lymphoid cells. SIVA1 expression is up-regulated in multiple pathological processes, little is known about the signaling pathway underlying the Siva-induced apoptosis. Recombinant human SIVA1 protein, fused to His-tag at N-terminus, was expressed in E. coli. (denatured)
Product Specifications
Product Name Alternative
Apoptosis regulatory protein Siva isoform 1, CD27BP, SIVA, Siva-1, Siva-2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
21.1 kDa (198aa)
Additionnal Information
References & Citations
Py B., et al. (2004) J Immunol. 172:4008-4017.; ; Chu F., et al. (2004) Apoptosis. 9:83-95.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea
Scientific Category
Apoptosis
NCBI Accession Number
NP_006418
Uniprot Accession Number
O15304
Species
Human
AA Sequence
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