KRAS inhibitor-22
KRAS inhibitor-22 (compound FB9/6B9) is a potent inhibitor of K-Ras. KRAS inhibitor-22 targets to Kras 4B (G12D) and (G12C), which can be used for cancer research[1].
Product Specifications
CAS Number
[2042365-57-9]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-inhibitor-22.html
Solubility
10 mM in DMSO
Smiles
O=C(N1C[C@H](CCC1)C(NCC(COC2=C(C(F)=CC(F)=C2F)F)=O)=O)C3=C(C=CC(Cl)=C3)OC
Molecular Formula
C23H21ClF4N2O5
Molecular Weight
516.87
References & Citations
[1]McCormick F, et al. Benzoylpiperidines and related compounds as K-Ras modulators and their preparation. World Intellectual Property Organization, WO2016179558 A1. 2016-11-10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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