KRAS inhibitor-22

KRAS inhibitor-22 (compound FB9/6B9) is a potent inhibitor of K-Ras. KRAS inhibitor-22 targets to Kras 4B (G12D) and (G12C), which can be used for cancer research[1].

Product Specifications

CAS Number

[2042365-57-9]

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kras-inhibitor-22.html

Solubility

10 mM in DMSO

Smiles

O=C(N1C[C@H](CCC1)C(NCC(COC2=C(C(F)=CC(F)=C2F)F)=O)=O)C3=C(C=CC(Cl)=C3)OC

Molecular Formula

C23H21ClF4N2O5

Molecular Weight

516.87

References & Citations

[1]McCormick F, et al. Benzoylpiperidines and related compounds as K-Ras modulators and their preparation. World Intellectual Property Organization, WO2016179558 A1. 2016-11-10.