Recombinant human ZNF346 protein
ZNF346 is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. ZNF346 may be involved in cell growth and survival. Recombinant human ZNF346 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Zinc finger protein 346, JAZ, Zfp346
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
35.3 kDa (317aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Schmitt J., et al. (2012) Int J Cancer. 131 (3) :673-82.; ; Yang M., et al. (1999) J Biol Chem. 274 (39) :27399-406.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_036411
Uniprot Accession Number
Q9UL40
Species
Human
AA Sequence
Frequently Asked Questions
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