Recombinant human PSG5 protein

PSG5 is a member of the PSG family, a group of closely related secreted glycoproteins that are highly expressed in fetal placental syncytiotrophoblast cells. PSGs become detectable in serum during the first two to three weeks of pregnancy and increase as the pregnancy progresses, eventually representing the most abundant fetal protein in the maternal blood at term. PSG5 function to stimulate secretion of TH2-type cytokines from monocytes, and they may also modulate the maternal immune system during pregnancy, thereby protecting the semi-allotypic fetus from rejection. Recombinant human PSG5 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Pregnancy-specific beta-1-glycoprotein 5, FL-NCA-3, PSG

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 80% by SDS-PAGE

Molecular Weight

36.4 kDa (324aa)

Additionnal Information

PSG5, Pregnancy-specific beta-1-glycoprotein 5, FL-NCA-3, PSG, ATGP2250-10 µg, ATGP2250-20 µg, ATGP2250-50 µg, ATGP2250-100 µg, ATGP2250-250 µg, ATGP2250-500 µg, ATGP2250-1 mg, ATGP2250-10, ATGP2250-20, ATGP2250-50, ATGP2250-100, ATGP2250-250, ATGP2250-500, ATGP2250-1

References & Citations

Chan W Y., et al. (1991) Mol Cell Biochem.106:161-170; ; Panzetta Dutari G M., et al. (2000) Biochem J. 2:511-519.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1M urea, 10% glycerol

Scientific Category

Other

NCBI Accession Number

NP_001123486

Uniprot Accession Number

Q15238

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSQVTIEAL PPKVSEGKDV LLLVHNLPQN LAGYIWYKGQ LMDLYHYITS YVVDGQINIY GPAYTGRETV YSNASLLIQN VTREDAGSYT LHIIKRGDRT RGVTGYFTFN LYLKLPKPYI TINNSKPREN KDVLAFTCEP KSENYTYIWW LNGQSLPVSP RVKRPIENRI LILPSVTRNE TGPYECEIRD RDGGMRSDPV TLNVLYGPDL PSIYPSFTYY RSGENLYLSC FAESNPPAEY FWTINGKFQQ SGQKLSIPQI TTKHRGLYTC SVRNSATGKE SSKSMTVEVS APSGIGRLPL LNPI