Recombinant human RAB21 protein

Ras-related protein Rab-21, also known as RAB21, is a member of the Ras superfamily of small GTP-binding proteins. Rab21 is integrin-associated protein and positive regulators of integrin traffic. This protein associate with the cytoplasmic domains of alpha-integrin chains and their expression influences the endo/exocytic traffic of integrins. This function of Rab21 is dependent on its GTP/GDP cycle and proper membrane targeting. Recombinant human RAB21 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Ras-related protein Rab-21, RAB21 member RAS oncogene family, KIAA0118

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

27.1 kDa (242aa) confirmed by MALDI-TOF

Additionnal Information

RAB21, Ras-related protein Rab-21, ATGP0907-10 µg, ATGP0907-20 µg, ATGP0907-50 µg, ATGP0907-100 µg, ATGP0907-250 µg, ATGP0907-500 µg, ATGP0907-1 mg, ATGP0907-10, ATGP0907-20, ATGP0907-50, ATGP0907-100, ATGP0907-250, ATGP0907-500, ATGP0907-1

References & Citations

Pellinen T., et al (2008) Dev. Cell 15:371-385; ; Opdam F.J.M., et al (2000) Eur. J. Cell Biol. 79:308-316

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 200 mM NaCl, 1mM PMSF

Scientific Category

Signal Transduction

NCBI Accession Number

NP_055814.1

Uniprot Accession Number

Q9UL25

Species

Human

AA Sequence

YSF KVVLLGEGCV GKTSLVLRYC ENKFNDKHIT TLQASFLTKK LNIGGKRVNL AIWDTAGQER FHALGPIYYR DSNGAILVYD ITDEDSFQKV KNWVKELRKM LGNEICLCIV GNKIDLEKER HVSIQEAESY AESVGAKHYH TSAKQNKGIE ELFLDLCKRM IETAQVDERA KGNGSSQPGT ARRGVQIIDD EPQAQTSGGG CC