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Recombinant human TGF-beta 1 protein

Transforming growth factor beta 1 (TGF-beta1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. Many cells synthesize TGFb1 and almost all of them have specific receptors for it. It positively and negatively regulates many other growth factors. Also, TGF-beta1 plays an important role in bone remodeling, controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Recombinant TGF-beta1 protein was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Transforming growth factor beta 1, CED, DPD1, TGFB, Transforming growth factor beta 1, TGFB1, TGFbeta, Camurati-Engelmann disease

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

12.9 kDa (113aa) confirmed by MALDI-TOF

Additionnal Information

TGF-b1, Transforming growth factor beta 1, CED, DPD1, TGFB, Transforming growth factor beta 1, TGFB1, TGFbeta, Camurati-Engelmann disease, TGFb1, TGF beta, ATGP0383-10 µg, ATGP0383-20 µg, ATGP0383-50 µg, ATGP0383-100 µg, ATGP0383-250 µg, ATGP0383-500 µg, ATGP0383-1 mg, ATGP0383-10, ATGP0383-20, ATGP0383-50, ATGP0383-100, ATGP0383-250, ATGP0383-500, ATGP0383-1

References & Citations

Lebman DA., et al. (1999) Microbes Infect. 1 (15) :1297-304.; ; Wahl SM., et al. (1988) J Immunol. 140 (9) :3026-32. ;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 10 mM Sodium Citrate buffer (pH 3.5) containing 10% glycerol

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_000651.3

Uniprot Accession Number

P01137

Species

Human

AA Sequence

MALDTNYCFS STEKNCCVRQ LYIDFRKDLG WKWIHEPKGY HANFCLGPCP YIWSLDTQYS KVLALYNQHN PGASAAPCCV PQALEPLPIV YYVGRKPKVE QLSNMIVRSC KCS

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