IDO1 Mouse Monoclonal Antibody [Clone ID: LBI2B5]
Product Specifications
Background
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan. [provided by RefSeq, Feb 2011]
Synonyms
IDO; IDO-1; INDO
Gene Name
Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA.
Gene ID
3620
UniProt
P14902
Conjugation
Unconjugated
Related Pathways
Metabolic pathways, Tryptophan metabolism
Field of Research
Metabolic pathways, Tryptophan metabolism
Dilution
WB 1:4000, IHC 1:150, IF 1:100
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
IDO1
Overview
Carrier-free (BSA/glycerol-free) IDO1 mouse monoclonal antibody, clone LBI2B5
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=3620
Uniprot URL
https://www.uniprot.org/uniprot/P14902
Curated Selection
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