Recombinant human Latexin protein
Latexin, a carboxypeptidase A inhibitor, is highly expressed in heart, prostate, ovary, kidney, pancrease, and colon, moderaqte or low in other tissues including brain. Latexin has no detectable sequence similarity with plant and parasite inhibitors, but it is related to a human putative tumor suppressor protein, TIG1. It is down-regulated in the presenilin-1-deficient mouse brain, thus putatively playing a role in Alzheimer's disease. Recombinant human Latexin protein was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
LXN, ECI, TCI, MuM, Endogenous carboxypeptidase inhibitor, Latexin, Latexin protein, Tissue carboxypeptidase inhibitor.
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
25.7 kDa (222aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
De Haan G., et al. (2007) . Nat Genet. 39 (2) :141-2; ; Aagaard A., et al. (2005) . Structure. 13 (2) :309-17;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 50 mM NaCl, 10% glycerol
Scientific Category
Enzymes & Proteases
NCBI Accession Number
NP_064554.2
Uniprot Accession Number
Q9BS40
Species
Human
AA Sequence
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