L-NAME (hydrochloride) (Standard)

L-NAME (hydrochloride) (Standard) is the analytical standard of L-NAME (hydrochloride) . This product is intended for research and analytical applications. L-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM.

Product Specifications

CAS Number

[51298-62-5]

Product Name Alternative

NG-Nitroarginine methyl ester hydrochloride (Standard)

UNSPSC

12352211

Target

NO Synthase; Reference Standards

Type

Reference Standards

Related Pathways

Immunology/Inflammation; Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/l-name-hydrochloride-standard.html

Smiles

N[C@@H](CCCNC(N[N+]([O-])=O)=N)C(OC)=O.[H]Cl

Molecular Formula

C7H16ClN5O4

Molecular Weight

269.69

References & Citations

[1]Pfeiffer S, et al. Inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME) : requirement forbioactivation to the free acid, NG-nitro-L-arginine. Br J Pharmacol. 1996 Jul;118 (6) :1433-40.|[2]Kopincová J, et al. L-NAME in the cardiovascular system - nitric oxide synthase activator? Pharmacol Rep. 2012;64 (3) :511-20.|[3]Lo HC, et al. The Nitric Oxide Synthase Inhibitor NG-Nitro-L-Arginine Methyl Ester Diminishes the Immunomodulatory Effects of Parental Arginine in Rats with Subacute Peritonitis. PLoSOne. 2016 Mar 23;11 (3) :e0151973.|[4]Luo H, et al. Effect of nitric oxide synthase inhibitor L-NAME on fear extinction in rats: a task-dependent effect. Neurosci Lett. 2014 Jun 20;572:13-8.|[5]Ocsan RJ, et al. Chronic NG-nitro-l-arginine methyl ester (L-NAME) administration in C57BL/6J mice induces a sustained decrease in c-kit positive cells during development of cardiac hypertrophy. J Physiol Pharmacol. 2013 Dec;64 (6) :727-36.|[6]V A Peotta, et al. Cardiovascular neural reflexes in L-NAME-induced hypertension in mice. Hypertension. 2001, 38, 3.|[7]Xiaofei Li, et al. Fucoidan from Undaria pinnatifida prevents vascular dysfunction through PI3K/Akt/eNOS-dependent mechanisms in the l-NAME-induced hypertensive rat model. Food Funct. 2016, 7, 5.