VU0080241

VU0080241 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 4 (mGluR4), with an EC50 of 4.6 μM[1].

Product Specifications

CAS Number

[393845-24-4]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu0080241.html

Purity

99.69

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC1CN(CCC1)C2=C3C(N(N=C3)C4=CC=C(C=C4C)C)=NC=N2

Molecular Formula

C19H23N5

Molecular Weight

321.42

References & Citations

[1]Colleen M Niswender, et al. Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) : Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators. Bioorg Med Chem Lett. 2008 Oct 15; 18 (20) : 5626-5630.