4,6-O-Ethylidene-α-D-glucose
Product Specifications
UNSPSC Description
4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose), a glucose derivative, is a competitive exofacial binding-site inhibitor on glucose transporter 1 (GLUT1) with a Ki of 12 mM for wild-type 2-deoxy-D-glucose transport[1][2][3].
Target Antigen
Endogenous Metabolite; GLUT
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/4-6-o-ethylidene-α-d-glucose.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)|H2O : 125 mg/mL (ultrasonic)
Smiles
[H][C@]12[C@@](O[C@H](O)[C@H](O)[C@H]2O)([H])COC(C)O1
Molecular Weight
206.194
References & Citations
[1]M Hashiramoto, et al. Site-directed Mutagenesis of GLUT1 in Helix 7 Residue 282 Results in Perturbation of Exofacial Ligand Binding. J Biol Chem. 1992 Sep 5;267(25):17502-7.|[2]Malay Patra, et al. A Potent Glucose-Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cells. Angew Chem Int Ed Engl. 2016 Feb 12;55(7):2550-4.|[3]G F Baker, et al. The Permeation of Human Red Cells by 4,6-O-ethylidene- -D-glucopyranose (Ethylidene Glucose). J Physiol. 1973 May;231(1):129-42.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N7433/4-6-O-Ethylidene-α-D-glucose-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N7433/4-6-O-Ethylidene-α-D-glucose-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
13224-99-2
Available Sizes
Curated Selection
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