M-RIP Polyclonal Antibody
Product Specifications
Background
Function:Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells., similarity:Contains 1 PH domain., similarity:Contains 2 PH domains., subcellular location:Colocalizes with F-actin., subunit:Binds F-actin through its N-terminus (By similarity) . Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.
Product Name Alternative
MPRIP; KIAA0864; MRIP; RHOIP3; Myosin phosphatase Rho-interacting protein; M-RIP; Rho-interacting protein 3; RIP3; p116Rip
Gene ID
23164
Swiss Prot
Q6WCQ1
Cross Reactivity
Human; Mouse; Rat
Clonality
Polyclonal
Source
Rabbit
Applications
IHC-p; IF (paraffin section) ; WB; ELISA
Dilution
WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Molecular Weight
110
Storage Conditions
-20°C/1 year
Protein Weight
110
Available Sizes
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