Akt (pan) mouse mAb

Catalytic activity:ATP + a protein = ADP + a phosphoprotein., disease:Defects in AKT1 are associated with breast cancer (BC) [MIM:114480]. BC is an extremely common malignancy, affecting one in eight women during their lifetime., disease:Defects in AKT1 are associated with colorectal cancer (CRC) [MIM:114500]., disease:Defects in AKT1 are associated with susceptibility to ovarian cancer [MIM:604370]; also called susceptibility to familial breast-ovarian cancer type 1 (BROVCA1) ., domain:Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI (3) K) results in its targeting to the plasma membrane., domain:The AGC-kinase C-terminal mediates interaction with THEM4., enzyme regulation:Three specific sites, one in the kinase domain (Thr-308) and the two other ones in the C-terminal regulatory region (Ser-473 and Tyr-474), need to be phosphorylated for its full activation., function:General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI (3) K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) . Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis, partly by playing a role in both insulin-induced phosphorylation of 4E-BP1 and in insulin-induced activation of p70 S6 kinase. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase., PTM:Phosphorylation on Thr-308, Ser-473 and Tyr-474 is required for full activity. Ser-473 phosphorylation by the Rictor-mTor complex favors Thr-308 phosphorylation by PDPK1. Ser-473 phosphorylation is enhanced by interaction with AGAP2 isoform 2 (PIKE-A) . Ser-473 phosphorylation is enhanced in focal cortical dysplasias with Taylor-type balloon cells., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily., similarity:Contains 1 AGC-kinase C-terminal domain., similarity:Contains 1 PH domain., similarity:Contains 1 protein kinase domain., subcellular location:Nucleus after activation by integrin-linked protein kinase 1 (ILK1) . Nuclear translocation is enhanced by interaction with TCL1A., subunit:Interacts with AGAP2 isoform 2 (PIKE-A) in the presence of guanine nucleotides. The C-terminus interacts with CCDC88A/GRDN and THEM4. Interacts with AKTIP. Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with CDKN1B; the interaction phosphorylates CDKN1B promoting 14-3-3 binding and cell-cycle progression., tissue specificity:In all human cell types so far analyzed.

AKT; AKT1; AKT1 kinase; AKT2; AKT2 kinase; Akt3; AKT3_HUMAN; CAKT; DKFZp434N0250; kinase Akt1; MGC99656; Murine thymoma viral (v-akt) homolog 2; PKB; PKB gamma; PKB-GAMMA; PKB/Akt; PKBALPHA; PKBB; PKBBETA; PKBG; PKBGAMMA; PRKBA; PRKBB; PRKBG; Protein kinase Akt-3; Protein kinase B; Protein kinase B gamma; RAC; rac protein kinase alpha; rac protein kinase beta; RAC-gamma; RAC-gamma serine/threonine-protein kinase; RAC-PK-gamma; RACALPHA; RACalpha serine/threonine kinase; RACBETA; RACgamma; RACgamma serine/threonine protein kinase; RACPKgamma; serine threonine protein kinase; STK-2; STK2; thymoma viral proto oncogene 1; thymoma viral proto oncogene; vakt murine thymoma viral oncogene homolog 1; vakt murine thymoma viral oncogene homolog 2; vakt murine thymoma viral oncogene homolog 3.