BMI-1026
BMI-1026 is a cyclin-dependent kinase 1 (Cdk1) inhibitor with IC50 of 2.3 nM. BMI-1026 induces apoptosis by arresting the G2-M phase[1].
Product Specifications
CAS Number
477726-77-5
UNSPSC
12352005
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bmi-1026.html
Smiles
OC1=CC=C(C=C1C2=NC(N)=NC=C2)C3=NC(N)=NC=C3
Molecular Formula
C14H12N6O
Molecular Weight
280.28
References & Citations
[1]Seong YS, et al. Characterization of a novel cyclin-dependent kinase 1 inhibitor, BMI-1026. Cancer Res. 2003 Nov 1;63 (21) :7384-91. Erratum in: Cancer Res. 2004 May 15;64 (10) :3725.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1
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