Voacamine
Product Specifications
UNSPSC Description
Voacamine, an indole alkaloid, exhibits potent cannabinoid CB1 receptor antagonistic activity[1]. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells[1].
Target Antigen
Cannabinoid Receptor; P-glycoprotein
Type
Natural Products
Related Pathways
GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/voacamine.html
Purity
99.64
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(OC)[C@]1([C@@H]2[N@](CC(C[C@H]2CC)C1)CC3)C4=C3C(C=C5OC)=C(N4)C=C5[C@](C[C@@H]6[C@H](C(OC)=O)[C@H](N(C)C/C6=C/C)C7)([H])C8=C7C9=C(N8)C=CC=C9
Molecular Weight
704.90
References & Citations
[1]Kitajima M, et al. Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1962-4.|[2]Meschini S, et al. Voacamine, an alkaloid extracted from <i>Peschiera fuchsiaefolia</i>, inhibits P-glycoprotein action in multidrug-resistant tumor cells. Int J Oncol. 2005 Dec;27(6):1597-603.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N6932/Voacamine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N6932/Voacamine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
3371-85-5
Available Sizes
Curated Selection
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