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(Asn10, Leu11, D-Trp12) -pTH-Related Protein (7-34) amide (human, mouse, rat)

Selected Variant

HY-P4385-01

Size: 5 mg

(Asn10, Leu11, D-Trp12) -pTH-Related Protein (7-34) amide (human, mouse, rat) is a potent PTH-1R antagonist[1][2].

Product Specifications

CAS Number

129622-68-0

UNSPSC

12352209

Target

PTHR

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/asn10-leu11-d-trp12-pth-related-protein-7-34-amide-human-mouse-rat.html

Purity

99.32

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

NC([C@H](C)NC([C@H]([C@H](O)C)NC([C@H](CC1=CN=CN1)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@H](CC(C)C)NC([C@H](CC2=CN=CN2)NC([C@H](CC3=CN=CN3)NC([C@H](CC(C)C)NC([C@H](CC4=CC=CC=C4)NC([C@H](CC5=CC=CC=C5)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CCC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](N)CC(C)C)=O)=O)CC6=CN=CN6)=O)=O)=O)CC7=CNC8=CC=CC=C78)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C162H254N50O36

Molecular Weight

3478.06

References & Citations

[1]Nutt RF, et al. Removal of partial agonism from parathyroid hormone (PTH) -related protein- (7-34) NH2 by substitution of PTH amino acids at positions 10 and 11. Endocrinology. 1990 Jul;127 (1) :491-3. |[2]Portal-Núñez S, et al. Parathyroid hormone-related protein exhibits antioxidant features in osteoblastic cells through its N-terminal and osteostatin domains. Bone Joint Res. 2018 Jan;7 (1) :58-68.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

PTH1R

Available Sizes

Price

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