AP-4-139B

AP-4-139B is a heat shock protein 70 inhibitor (IC50=180 nM) . HSP70 is a protein that is overexpressed in many types of cancer and is closely related to the survival and proliferation of tumor cells. AP-4-139B exhibits significant cytotoxicity to tumor cells, particularly in colorectal cancer cells. AP-4-139B can be used for cancer research[1][2].

Product Specifications

CAS Number

[2716909-84-9]

UNSPSC

12352005

Target

HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ap-4-139b.html

Purity

98.87

Smiles

C1([P+](C2=CC=CC=C2)(C3=CC=CC=C3)CCCCCCC4=NN5C=C(N=C5S4)C6=CC=CC=C6)=CC=CC=C1.[Br-]

Molecular Formula

C34H33BrN3PS

Molecular Weight

626.59

References & Citations

[1]Barnoud T, et al. A novel inhibitor of HSP70 induces mitochondrial toxicity and immune cell recruitment in tumors[J]. Cancer research, 2020, 80 (23) : 5270-5281.|[2]Ferretti G D S, et al. HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer[J]. Cell Death & Differentiation, 2024: 1-16.