Phospho-HRH1 (Ser398) Polyclonal Antibody

Product Specifications

Background

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].

Synonyms

HRH1phospho S398; H1R; HisH1; Histamine H1 receptor; Histamine receptor H1; Histamine receptor subclass H1.

Gene ID

3269

Modification Site

Ser398

Cellular Locus

Cell membrane

Host

Rabbit

Cross Reactivity

Mouse, Rabbit

Target

Phospho-HRH1 (Ser398)

Clonality

Polyclonal

Conjugation

Unconjugated

Source

KLH conjugated synthetic phosphopeptide derived from human HRH1 around the phosphorylation site of Ser398 [SH (p-S) RQ]

Applications

WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Concentration

1ug/ul

Dilution

WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Prediction Reactivity

Human, Rat, Dog, Cow, Pig, Horse, GuineaPig

Gene ID URL

3269

Isotype

IgG

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