Phospho-Bax (Ser184) Polyclonal Antibody, Cy5 Conjugated

Product Specifications

Background

Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

Synonyms

BCL2L4; Apoptosis regulator BAX; Bcl-2-like protein 4; Bcl2-L-4; BAX

Gene ID

581

Swiss Prot

Q07812

Modification Site

Ser184

Cellular Locus

Cytoplasm, Cell membrane

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Target

Phospho-Bax (Ser184)

Clonality

Polyclonal

Conjugation

Cy5

Source

KLH conjugated synthetic phosphopeptide derived from human Bax around the phosphorylation site of Ser184

Applications

WB, IF, Flow-Cyt

Purification

Purified by Protein A.

Excitation Emission

625,650nm/670nm

Concentration

1ug/ul

Dilution

WB (1:300-5000), IF (), Flow-Cyt (1ug/Test)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Prediction Reactivity

Dog, Cow, Sheep, Pig

Gene ID URL

581

Isotype

IgG

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