KOR agonist 2

KOR agonist 2 (Compound 23p) is an agonist for κ opioid receptor (KOR) with Ki of 1.9 nM. KOR agonist 2 exhibits analgesic effect in mouse models with ED50 of 1.30 mg/kg. KOR agonist 2 exhibits high clearance rate (2 mg/kg, i.v.) in mice, high metabolism and clearance in liver microsomes[1].

Product Specifications

CAS Number

[3050912-29-0]

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/kor-agonist-2.html

Smiles

O=S(C1=CC=CC(Cl)=C1)(N(CC2=CC=CC=C2)[C@@H]3C[C@H](CN(C)C)[C@](C4=CC=CC(OC)=C4)(O)CC3)=O

Molecular Formula

C29H35ClN2O4S

Molecular Weight

543.12

References & Citations

[1]Gao Y, et al., Discovery of N'-benzyl-3-chloro-N- ((1S,3R,4R) -3- ((dimethylamino) methyl) -4-hydroxy-4- (3-methoxyphenyl) cyclohexyl) benzenesulfonamide as a novel selective KOR ligand. Eur J Med Chem. 2024 Jul 3;276:116643.