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Phospho-PKC zeta (T560) Monoclonal Antibody

Product Specifications

Background

Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

Synonyms

14-3-3-zetaisoform antibody, AI098070 antibody, aPKCzeta antibody, C80388 antibody, EC 2.7.11.13 antibody, KPCZ_HUMAN antibody, nPKC zeta antibody, nPKC-zeta antibody, OTTHUMP00000001368 antibody, OTTHUMP00000044160 antibody, PKC 2 antibody, PKC ZETA antibody, PKC2 antibody, Pkcz antibody, PKCZETA antibody, PKM-zeta, included antibody, PRKCZ antibody, Protein kinase C zeta antibody, Protein kinase C zeta form antibody, Protein kinase C zeta type antibody, r14-3-3 antibody, R74924 antibody, zetaPKC antibody

Gene ID

5590

Swiss Prot

Q05513

Modification Site

Thr560

Cellular Locus

Cytoplasm, Endosome, Cell junction

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Target

Phospho-PKC zeta (T560)

Clonality

Monoclonal

Isotype

IgG

Clone

10B1

Conjugation

Unconjugated

Source

Synthetic phospho-Peptide corresponding to residues surrounding Thr560 of human PKC zeta.

Applications

WB, IHC-P, IHC

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

WB (1:300-5000), IHC-P (1:200-400), IHC ()

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C for 12 months.

Gene ID URL

5590

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