SPTAN1 (4C8) Monoclonal Antibody
Product Specifications
Background
Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. SPTAN1 is an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants. SPTAN1, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus a candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Synonyms
Spectrin alpha chain non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain; Spectrin non-erythroid alpha subunit; NEAS; SPTA2
Gene ID
6709
Swiss Prot
Q13813
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
SPTAN1
Clonality
Monoclonal
Isotype
IgG
Clone
4C8
Conjugation
Unconjugated
Source
Recombinant protein within human Alpha Fodrin aa 2300-2450
Applications
WB, IHC-P
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene ID URL
6709
Curated Selection
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