What is the catalog number for GSK2606414?

The catalog number for GSK2606414 is bs-83000C.

What sizes are available for GSK2606414?

GSK2606414 is available in the following size(s): 5 mg, 25 mg.

How many pack sizes does GSK2606414 come in?

GSK2606414 is available in 2 different pack sizes.

Is GSK2606414 in stock?

GSK2606414 is currently made to order / not held in immediate stock. Contact us for lead time.

GSK2606414

Product Specifications

Background

Potent (IC50 = 0.4 nM) and selective (against a panel of 294 kinases) inhibitor of protein kinase R-like endoplasmic reticulum kinase (PERK), an important effector of the unfolded protein response (UPR) .1 It prevented neurodegeneration in a mouse model of frontotemporal dementia2 and rodent models of Parkinsons disease via modulation of the UPR3. GSK2606414 has been reported to be a potent inhibitor of RIPK1 (IC50 = 18 nM) .4 It has also displayed neuroprotective effects in various models of stroke.5-7