LY2603618
Product Specifications
Background
LY2603618 is a potent (IC50 = 7nM) and selective (>1000x over Chk2) Checkpoint kinase 1 (Chk1) inhibitor.1 Chk1 is an important regulator of the DNA damage response – combination treatment of LY2603618 with other chemotherapeutic agents significantly increased tumor growth inhibition when compared to chemotherapeutic alone.2,3,4 LY2603618 caused a dramatic suppression of cell growth in MCF-7 and MDA-MB-231 human breast cancer cells via Chk1 inhibition induced upregulation of replication stress caused by oncogenes.5
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
N004278 2 Card (2 Marker (s) x 1 Card)
GLYCERINE450X52CARD-T1-P2 Pipe Markers for Gases
Sign In for Pricing
View Details 
TP319053 20 µg
NIR1 (PITPNM3) (NM_031220) Human Recombinant Protein
Sign In for Pricing
View Details