MAPE Antibody / PRAME
MAPE (Melanoma antigen preferentially expressed in tumors), also called PRAME (Preferentially expressed antigen of melanoma), is a protein that is preferentially expressed in tumors, particularly in melanoma. It plays a vital role in regulating cell proliferation, migration, and invasion, making it a promising target for therapeutic interventions. Studies have shown that the overexpression of MAPE protein is associated with aggressive melanoma subtypes, indicating its potential as a prognostic biomarker in melanoma patients.
Product Specifications
Specifications
Western blot: 1:1000-1:2000, Immunohistochemistry (FFPE) : 1:50-1:100, Flow cytometry: 1:25 per million cells in 0.1ml
UniProt
P78395
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 476-502 from the human protein was used as the immunogen for the MAPE antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P, FACS
Purity
Antigen affinity
Format
Purified
Limitations
This MAPE antibody is available for research use only.
Storage Conditions
Aliquot the MAPE antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Location
Cytoplasm, Nucleus, Cell Membrane
Image Legend
IHC staining of FFPE human testis tissue with MAPE antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.
Frequently Asked Questions
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