STK11 Mouse Monoclonal Antibody
Product Specifications
Background
Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.serine/threonine kinase 11, with two alternatively spliced isoforms, expressed in all tissues, strongly homolog of Xenopus early embryonic kinase 1 (XEEK1), tumor suppressor gene in hamartomas syndrome and in left sided colon carcinogenesis, mutated in sporadic testicular cancer, malignant melanomas and laryngeal tumors, playing a minor role in the development of ovarian carcinoma.LKB1 is a potential target for atherosclerosis and cancer and is shown to be mutated in patients with Peutz-Jeghers cancer syndrome. Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver.
Product Name Alternative
PJS; LKB1; STK11
Gene Name
STK11
Gene ID
6794
Swiss Prot
Q15831
Host
Mouse
Reactivity
Human, Mouse, Monkey
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, ELISA, FC
Field of Research
Autophagy, Apoptosis, PI3K-Akt signaling pathway
Purification
Affinity Purification
Dilution
WB 1:500-1:2000, ELISA 1:5000-1:20000, FC 1:200-1:400
Form
Liquid
Buffer
Ascitic fluid containing 0.03% sodium azide.
Modification
Unmodified
Molecular Weight
54kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Isotype
Mouse IgG1
Available Sizes
Curated Selection
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