[Phe2]-TRH

[Phe2]-TRH is a thyrotropin releasing hormone analogue, equipping a conformational similarity with Leu5-enkephalin[1].

Product Specifications

CAS Number

34783-35-2

UNSPSC

12352209

Target

Thyroid Hormone Receptor

Type

Peptides

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/phe2-trh.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H]1CCC(N1)=O)N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(N)=O)=O

Molecular Formula

C19H24N4O4

Molecular Weight

372.42

References & Citations

[1]Eckle E, et al. Conformational properties of central nervous system active thyrotropin releasing hormone analogues: probing structure-activity relationships at the molecular level. J Med Chem. 1985 Jan;28 (1) :125-37. |[2]Zhang WJ, et al. Impact of azaproline on amide cis-trans isomerism: conformational analyses and NMR studies of model peptides including TRH analogues. J Am Chem Soc. 2003 Feb 5;125 (5) :1221-35.