EF-2 Rabbit Polyclonal Antibody

This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008], function:This protein promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome., PTM:Diphthamide is 2-[3-carboxyamido-3- (trimethyl-ammonio) propyl]histidine. Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A., PTM:Phosphorylation by EF-2 kinase completely inactivates EF-2., similarity:Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily., subunit:Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9.