TIF1α Rabbit Polyclonal Antibody

The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008], disease:A chromosomal aberration involving TIF1 is a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Translocation t (7;10) (q32; q11) with RET. The translocation generates the TIF1/RET (PTC6) oncogene., function:Interacts selectively in vitro with the AF2-activating domain of the estrogen receptors. Association with DNA-bound estrogen receptors requires the presence of estradiol., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 bromo domain., similarity:Contains 1 PHD-type zinc finger., similarity:Contains 1 RING-type zinc finger., similarity:Contains 2 B box-type zinc fingers., subunit:Interacts with CBX1 and CBX3 (By similarity) . Interacts with NR3C2.

TRIM24; RNF82; TIF1; TIF1A; Transcription intermediary factor 1-alpha; TIF1-alpha; E3 ubiquitin-protein ligase TRIM24; RING finger protein 82; Tripartite motif-containing protein 24