ROS1 (phospho-Tyr2274) Rabbit Polyclonal Antibody

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008], catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., disease:A chromosomal aberration involving ROS1 is found in glioblastoma multiform (GBM) . An homozygous deletion in chromosome 6q21 results in expression of a GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity., function:This is probably a cell growth or differentiation factor receptor with a tyrosine-protein kinase activity., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 9 fibronectin type-III domains.

Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)