Ebselen

Glutathione peroxidase mimic

Product Specifications

Background

Ebselen or 2-phenyl-1, 2-benzisoselenazol-3(2H)-one (also called PZ 51 or DR3305), is a mimic of glutathione peroxidase and can also react with peroxynitrite (1). It is being investigated as a possible treatment for reperfusion injury and stroke (2, 3), as well as tinnitus (4). Ebselen is a potent scavenger of hydrogen peroxide as well as hydroperoxides including membrane bound phospholipid and cholesterylester hydroperoxides.

CAS Number

60940-34-3

Product Name Alternative

2-Phenyl-1,2-benzoselenazol-3 (2H) -one

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cancer | Apoptosis

Purity

>99%

Weight

0.01

Format

Off-white Solid

Solubility

Soluble in DMSO and 100% ethanol

Molecular Formula

C13H9NOSe

Molecular Weight

274.18

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Schewe T. (1995) Gen Pharmacol. 26(6): 1153-1169. 2. Parnham M., Seis H. (2000) Expert Opin Investig Drugs. 9(3): 607-619. 3. Yamaguchi T., et al. (1998) Stroke. 29(1): 12-17. 4. Kil J., Pierce C., Tran H., Gu R., Lynch E.D. (2007) Hearing Research. 226(1-2): 44-51.