Ebselen
Protein Kinase C inhibitor
Product Specifications
Background
Ebselen or 2-phenyl-1, 2-benzisoselenazol-3(2H)-one (also called PZ 51 or DR3305), is a mimic of glutathione peroxidase and can also react with peroxynitrite (1). It is being investigated as a possible treatment for reperfusion injury and stroke (2, 3), as well as tinnitus (4). Ebselen is a potent scavenger of hydrogen peroxide as well as hydroperoxides including membrane bound phospholipid and cholesterylester hydroperoxides.
Product Name Alternative
2-Phenyl-1,2-benzoselenazol-3(2H)-one
UNSPSC
41116105
Source
Synthetic
Purity
>99%
Weight
0.01
Format
Off-white Solid
Solubility
Soluble in DMSO and 100% ethanol
Molecular Formula
C13H9NOSe
Molecular Weight
274.18
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Schewe T. (1995) Gen Pharmacol. 26(6): 1153-1169.
2. Parnham M., Seis H. (2000) Expert Opin Investig Drugs. 9(3): 607-619.
3. Yamaguchi T., et al. (1998) Stroke. 29(1): 12-17.
4. Kil J., Pierce C., Tran H., Gu R., Lynch E.D. (2007) Hearing Research. 226(1-2): 44-51.
CAS Number
60940-34-3
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