PDE6G Rabbit Polyclonal Antibody

This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009], catalytic activity:Guanosine 3',5'-cyclic phosphate + H (2) O = guanosine 5'-phosphate., function:Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones., online information:Retina International's Scientific Newsletter, similarity:Belongs to the rod/cone cGMP-PDE gamma subunit family., subunit:Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.