PDZK3 Rabbit Polyclonal Antibody

The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16) . Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. [provided by RefSeq, Dec 2015], disease:May be associated with the early promotion of prostate tumoregenesis., PTM:A secreted form is produced by caspase-mediated proteolytic cleavage., similarity:Contains 1 PDZ (DHR) domain., similarity:Contains 6 PDZ (DHR) domains., subcellular location:At cell-cell contacts in lung epithelial cells., subunit:Interacts with SCN10A, CTNND2 and PKP4., tissue specificity:Expressed (at protein level) in prostate and many prostate tumors.